Jo Jo Gunne started after former Spirit band members Jay Ferguson and Mark Andes banded together with Mark's brother Matt on guitar and Curly Smith on percussion. Jo Jo Gunne released four albums over a period of two years on the newly formed Asylum Records before they disbanded. One of the albums spawned a Top 40 hit in the US called Run, Run, Run.

After many years, the band has reunited with a new release in 2005 called Big Chain.